Processed, processed food is part of so-called junk food. While it initially appears to reduce the incidence of infectious diseases such as those caused by contaminated food (for example, E. coli), it may increase the risk of developing chronic low-grade infections and inflammation of a certain magnitude such as diabetes. . This is suggested by a new study conducted by scientists from Georgia State University. Here are the details of the research. Diet, diabetes and health
Diet can make a difference in terms of health, especially when it comes to chronic diseases. The study, conducted on an animal model, showed that switching from a healthy cereal-based diet to a highly processed, high-fat Western one affects a bacterium called Citrobacter rodentium, which closely resembles Escherichia coli (E. coli) in ‘human being. It is important to remember that the intestinal microbiota has the function of protecting the intestine from pathogens. These microorganisms are influenced by a variety of environmental factors, particularly diet, and are highly dependent on complex carbohydrates such as fiber. The Western-style diet, which contains high amounts of processed foods, red meat, high-fat dairy products, high-sugar foods and prepackaged foods, it lacks fiber, which is necessary to support the gut microbiota. Changes in eating habits, particularly a lack of fiber, are believed to have contributed to increasing the prevalence of chronic inflammatory diseases such as inflammatory bowel disease, metabolic syndrome and cancer. In this study, the researchers found that switching mice from a regular grain-based rodent food to a high-fat, low-fiber Western-style diet resulted in a rapid reduction in the number of gut bacteria. have contributed to increasing the prevalence of chronic inflammatory diseases such as inflammatory bowel disease, metabolic syndrome and cancer. In this study, the researchers found that switching mice from a regular grain-based rodent food to a high-fat, low-fiber Western-style diet resulted in a rapid reduction in the number of gut bacteria. have contributed to increasing the prevalence of chronic inflammatory diseases such as inflammatory bowel disease, metabolic syndrome and cancer. In this study, the researchers found that switching mice from a regular grain-based rodent food to a high-fat, low-fiber Western-style diet resulted in a rapid reduction in the number of gut bacteria.Low-fiber diet can lead to diabetes
Researchers showed that switching from a grain-based diet to a Western-style diet reduced the human body’s ability to eliminate the pathogen Citrobacter rodentium from the colon. Mice fed this diet were also prone to developing chronic infections when challenged again by this pathogen. In practice, the Western-style diet reduces the number of gut bacteria and promotes invasion of the microbiota in the gut, potentially affecting the readiness of the immune system and the body’s defense against pathogenic bacteria. ‘We observed that feeding mice a Western-style diet, rather than standard grain-based rodent food, altered the dynamics of Citrobacter infection by reducing initial colonization and inflammation,’ which was surprising. However, mice consuming the Western-style diet often developed persistent infection associated with low-grade inflammation and insulin resistance. These studies demonstrate the potential alteration of the microbiota and its metabolites through diet, affecting the course and consequences of infection following exposure to an intestinal pathogen, “explains Dr. Andrew Gewirtz, senior co-author of the study and professor at the Institute of Biomedical Sciences. “We hypothesize that remodeling of the gut microbiota by nutrients that promote beneficial bacteria that outperform pathogens may be a means of broadly promoting health,” concludes Jun Zou, senior co-author of the study and assistant professor at the Institute for Biomedical Sciences. .Fonti scientifiche
Junqing An, Xu Zhao, Yanling Wang, Juan Noriega, Andrew T. Gewirtz, Jun Zou. Western-style diet impedes colonization and clearance of Citrobacter rodentium. PLOS Pathogens, 2021; 17 (4): e1009497 DOI: 10.1371/journal.ppat.1009497
