If we observe the world of nature carefully we notice that it is a perfect system, which does not make mistakes and does not alter. The sunrise, for example, always changes but follows precise rules unchanged for millennia. Like our star, our organism also follows very precise biological rhythms that should never be altered. Several studies have in fact confirmed the importance of our circadian cycle. This cycle, according to the latest research, would also seem to be directly involved with the times we eat. So eating at one hour rather than another could really make a difference in terms of body weight and health. The clocks of our body and the chronodiet
According to scientists from the National Research Institute for Food (NFRI) and the Biological Clock Research Group, ‘the central clock that dominates the rhythms of activity is affected by the cycles of light and dark, while the peripheral clocks that regulate local metabolic rhythms are determined by the cycles of eating and fasting “. So «Since the circadian system organizes the entire energy homeostasis, including food intake, fat accumulation and calorie expenditure, the disruption of circadian clocks leads to metabolic disturbances. Recent results show that timed feeding, limited during the active phase, amplifies circadian clocks and improves metabolic disturbances induced by a high-fat diet without calorie reduction.The liver, rhythms of the organism and chronodieta
Recent studies have shown how specific diets, prolonged for a week, are able to alter the phase of circadian expression of genes controlled by the peripheral clock. This does not seem to affect the central clock modified by the sleep wake and light / dark rhythms. The liver appears to take about 3 days to adapt to various changes, while other organs such as the heart, kidneys, pancreas and lungs take longer. From the studies “it was revealed that the balance between food volume and hunger intervals is an important factor in determining the phase of the liver clock”. In particular, it seems that breakfast is the most important time to regulate the liver clock. On the other hand,Carbohydrates, proteins and chronology
Scientists have discovered that the substances capable of modifying rhythms are mostly carbohydrates and proteins. For this reason these two components – when taken together – should be avoided at specific times of the day. Chronodiet and scientific studies
A recent study published in Cell Metabolism highlighted how you can lose weight and improve your health by eating only during the day. In the dark hours, in fact, there is an alteration of the metabolism and an accumulation of toxins. To get the best results it is also important to follow specific times. For example, in the morning between seven and eight, our organism is at maximum metabolic activity. In these hours, therefore, we can also allow ourselves some gluttony. By 8 o’clock the insulin reaches its peak, therefore a few more sugars are allowed which gives us immediate energy. Lunch, on the other hand, should be eaten between 12 and 13, a time when the levels of thyroid hormones are particularly high. At this time we should eat mainly carbohydrates such as pasta, bread and rice. Dinner should be consumed between 19 and 20. But it would be advisable to avoid, at these times, the intake of sugars and carbohydrates. During these hours you should consume proteins from fish, meat or legumes. In fact, during the evening there is an increase in the production of somatostatin, a substance that promotes the formation of lean mass and a decrease in insulin.Chronodiet, yes and eat at the right time Lose Weight Instead of Gain Weight
We all know that following a high-fat diet increases the risk of obesity. However, a controlled diet, in terms of schedules, eliminates the risk without reducing calories. “This extraordinary effect – explain the researchers – is probably due to the tuning of circadian clocks”. With the chronodiet you are less hungry
Circadian clocks control the expression of leptin, a substance that naturally suppresses appetite. On the contrary, «the circadian misalignment causes a reduction of leptin in the serum. In fact, some studies have found that altered feeding rhythms lead to an increase in total food intake. While leptin levels are reduced and energy intake is increased during short sleep periods in humans. Reduce the risk of cardiovascular and metabolic diseases with the chronodiet

Some studies have shown that eating irregularly – therefore without following a chronodiet – increases cardio-metabolic risk factors and cardiovascular diseases. All this is probably due to a worse metabolization of the ingested substances. Scientific sources
[1] Hirao A, Nagahama H, Tsuboi T, Hirao M, Tahara Y, Shibata S. Combination of starvation interval and food volume determines the phase of liver circadian rhythm in Per2 :: Luc knock-in mice under two meals per day feeding. Am J Physiol Gastrointest Liver Physiol. 2010; 299 (5): G1045–53. doi: 10.1152 / ajpgi.00330.2010.
[2] Kuroda H, Tahara Y, Saito K, Ohnishi N, Kubo Y, Seo Y, et al. Meal frequency patterns determine the phase of mouse peripheral circadian clocks. Sci Rep. 2012; 2: 711. doi: 10.1038 / srep00711.
[3] Hirao A, Tahara Y, Kimura I, Shibata S. A balanced diet is necessary for proper entrainment signals of the mouse liver clock. PLoS One. 2009;4(9):e6909. doi: 10.1371/journal.pone.0006909.
[4] Gomez Abellan P, Gomez Santos C, Madrid JA, Milagro FI, Campion J, Martinez JA, et al. Site-specific circadian expression of leptin and its receptor in human adipose tissue. Nutr Hosp. 2011;26(6):1394–401
[5] Curr Nutr Rep. 2014; 3(3): 204–212. Published online 2014 Apr 27. doi: 10.1007/s13668-014-0082-6 PMCID: PMC4118017 Nutrients, Clock Genes, and Chrononutrition Hideaki Oike,corresponding author Katsutaka Oishi, and Masuko Kobori Food Function Division, National Food Research Institute (NFRI), National Agriculture and Food Research Organization (NARO), 2-1-12 Kannondai, Tsukuba, Ibaraki 305-8642 Japan Biological Clock Research Group, Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Central 6, 1-1-1 Higashi, Tsukuba, Ibaraki 305-8566 Japan Department of Medical Genome Sciences, Graduate School of Frontier Sciences, University of Tokyo, Kashiwa, Japan Department of Applied Biological Science, Graduate School of Science and Technology, Tokyo University of Science, Noda, Japan

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